Please do not rely on this page for the details of future fixtures—it may not be up-to-date. Instead, check the official Sydney FC website.
| Comp | Rd | Date | Time (Sydney time) | Vs | Venue | Referee | Crowd | Result | MOTM |
|---|---|---|---|---|---|---|---|---|---|
| A-L | W2 | 2 Jan 2021 | 5:00 pm | Wellington Phoenix FC | WIN Stadium (A) | King | 3,637 | 2-1 | Nieuwenhof |
| A-L | W4 | 16 Jan 2021 | 5:00 pm | Western Sydney Wanderers FC | Stadium Australia (H) | King | 14,402 | 1-1 | Ninković |
| A-L | W5 | 22 Jan 2021 | 7:00 pm | Central Coast Mariners FC | Netstrata Jubilee Stadium (H) | Abraham | 5,320 | 0-2 | Cáceres |
| A-L | W6 | 30 Jan 2021 | 7:10 pm | Macarthur FC | Campbelltown Stadium (A) | King | ? | 3-0 | Ninković |
| A-L | W7 | 8 Feb 2021 | 7:15 pm | Wellington Phoenix FC | Netstrata Jubilee Stadium (H) | Beath | 5,220 | 2-1 | Barbarouses |
| A-L | W9 | 20 Feb 2021 | 7:15 pm | Brisbane Roar FC | Netstrata Jubilee Stadium (H) | Beath | 5,667 | 0-0 | Ninković |
| A-L | W9 | 23 Feb 2021 | 7:05 pm | Melbourne City FC | AAMI Park (A) | Lucas | 3,868 | 2-3 | Ninković |
| A-L | W10 | 28 Feb 2021 | 4:05 pm | Macarthur FC | Netstrata Jubilee Stadium (H) | King | 10,158 | 0-1 | Ninković |
| A-L | W11 | 6 Mar 2021 | 4:05 pm (5:05 pm) |
Brisbane Roar FC | Moreton Daily Stadium (A) | Evans | 8,562 | 1-1 | McGowan |
| A-L | W11 | 10 Mar 2021 | 7:05 pm | Western United FC | Netstrata Jubilee Stadium (H) | Elder | 5,201 | 2-0 | Grant |
| A-L | W12 | 13 Mar 2021 | 5:05 pm | Newcastle United Jets FC | Netstrata Jubilee Stadium (H) | Abraham | 8,920 | 2-1 | Wilkinson |
| A-L | W13 | 24 Mar 2021 | 6:20 pm (9:20 pm) |
Perth Glory FC | HBF Park (A) | Faghani | 4,273 | 1-1 | Bobô |
| A-L | W14 | 28 Mar 2021 | 5:40 pm (6:10 pm) |
Adelaide United FC | Coopers Stadium (A) | Evans | 8,451 | 0-1 | McGowan |
| A-L | W15 | 4 Apr 2021 | 7:05 pm | Melbourne Victory FC | AAMI Park (A) | Elder | 5,347 | 3-0 | Barbarouses |
| A-L | W15 | 7 Apr 2021 | 7:50 pm | Perth Glory FC | Netstrata Jubilee Stadium (H) | Kersey | 5,122 | 1-0 | Barbarouses |
| A-L | W16 | 10 Apr 2021 | 5:05 pm | Melbourne City FC | Leichhardt Oval (H) | King | 7,676 | 1-1 | Brattan |
| A-L | W17 | 18 Apr 2021 | 4:05 pm | Adelaide United FC | Leichhardt Oval (H) | Evans | 7,718 | 2-2 | Bobô |
| A-L | W18 | 24 Apr 2021 | 5:05 pm | Central Coast Mariners FC | Central Coast Stadium (A) | Beath | 10,173 | 2-2 | Ninković |
| A-L | W18 | 27 Apr 2021 | 7:35 pm | Melbourne Victory FC | Netstrata Jubilee Stadium (H) | Elder | 4,816 | 1-0 | Bobô |
| A-L | W19 | 1 May 2021 | 7:10 pm | Western Sydney Wanderers FC | Bankwest Stadium (A) | Evans | 20,336 | 2-3 | Cáceres |
| A-L | W20 | 8 May 2021 | 5:05 pm | Newcastle United Jets FC | McDonald Jones Stadium (A) | King | 4,404 | 1-1 | Ninković |
| A-L | W21 | 15 May 2021 | 2:35 pm | Western United FC | Mars Stadium (A) | Evans | 2,020 | 1-0 | Ninković |
| A-L | W21 | 19 May 2021 | 7:05 pm | Melbourne Victory FC | Netstrata Jubilee Stadium (H) | King | 4,226 | 2-0 | Ninković |
| A-L | W22 | 23 May 2021 | 4:05 pm | Western Sydney Wanderers FC | Sydney Cricket Ground (H) | Beath | 17,121 | 1-0 | King |
| A-L | W23 | 29 May 2021 | 6:40 pm (7:10 pm) |
Adelaide United FC | Coopers Stadium (A) | Elder | 8,198 | 4-1 | Le Fondre |
| A-L | W24 | 5 Jun 2021 | 3:05 pm | Brisbane Roar FC | Moreton Daily Stadium (A) | Faghani | 8,351 | 2-0 | Heward-Belle |
| A-L | SF | 19 Jun 2021 | 7:05 pm | Adelaide United FC | Netstrata Jubilee Stadium (H) | Faghani | 6,033 | 2-1 | King |
| A-L | GF | 27 Jun 2021 | 5:05 pm | Melbourne City FC | AAMI Park (A) | Beath | 14,017 | 1-3 | Heward-Belle |